Design study of Software-Implemented Fault-Tolerance (SIFT) computer

Software-implemented fault tolerant (SIFT) computer design for commercial aviation is reported. A SIFT design concept is addressed. Alternate strategies for physical implementation are considered. Hardware and software design correctness is addressed. System modeling and effectiveness evaluation are considered from a fault-tolerant point of view

High-Energy Passive Mode-Locking of Fiber Lasers

Mode-locking refers to the generation of ultrashort optical pulses in laser systems. A comprehensive study of achieving high-energy pulses in a ring cavity fiber laser that is passively mode-locked by a series of waveplates and a polarizer is presented in this paper. Specifically, it is shown that the multipulsing instability can be circumvented in favor of bifurcating to higher-energy single pulses by appropriately adjusting the group velocity dispersion in the fiber and the waveplate/polarizer settings in the saturable absorber. The findings may be used as practical guidelines for designing high-power lasers since the theoretical model relates directly to the experimental settings

Stability of stationary states in the cubic nonlinear Schroedinger equation: applications to the Bose-Einstein condensate

The stability properties and perturbation-induced dynamics of the full set of stationary states of the nonlinear Schroedinger equation are investigated numerically in two physical contexts: periodic solutions on a ring and confinement by a harmonic potential. Our comprehensive studies emphasize physical interpretations useful to experimentalists. Perturbation by stochastic white noise, phase engineering, and higher order nonlinearity are considered. We treat both attractive and repulsive nonlinearity and illustrate the soliton-train nature of the stationary states.Comment: 9 pages, 11 figure

Stability of Attractive Bose-Einstein Condensates in a Periodic Potential

Using a standing light wave trap, a stable quasi-one-dimensional attractive dilute-gas Bose-Einstein condensate can be realized. In a mean-field approximation, this phenomenon is modeled by the cubic nonlinear Schr\"odinger equation with attractive nonlinearity and an elliptic function potential of which a standing light wave is a special case. New families of stationary solutions are presented. Some of these solutions have neither an analog in the linear Schr\"odinger equation nor in the integrable nonlinear Schr\"odinger equation. Their stability is examined using analytic and numerical methods. Trivial-phase solutions are experimentally stable provided they have nodes and their density is localized in the troughs of the potential. Stable time-periodic solutions are also examined.Comment: 12 pages, 18 figure

Berry phases for the nonlocal Gross-Pitaevskii equation with a quadratic potential

A countable set of asymptotic space -- localized solutions is constructed by the complex germ method in the adiabatic approximation for the nonstationary Gross -- Pitaevskii equation with nonlocal nonlinearity and a quadratic potential. The asymptotic parameter is 1/T, where $T\gg1$ is the adiabatic evolution time. A generalization of the Berry phase of the linear Schr\"odinger equation is formulated for the Gross-Pitaevskii equation. For the solutions constructed, the Berry phases are found in explicit form.Comment: 13 pages, no figure

Normal growth and development in mice over-expressing the CCN family member WISP3

Loss-of-function mutations in the gene WISP3 cause the autosomal recessive human skeletal disease Progressive Pseudorheumatoid Dysplasia, whereas mice with knockout mutations of Wisp3 have no phenotype. The lack of a phenotype in the Wisp3 knockout mice has constrained studies of the protein’s in vivo function. Over-expression experiments in zebrafish indicated that WISP3 may function as a BMP and Wnt signaling modulator. To determine whether these biologic activities are retained in mice, we created two strains of transgenic mice that over-express WISP3 in a broad array of tissues. Despite strong and persistent protein over-expression, the transgenic mice remained phenotypically indistinguishable from their non-transgenic littermates. Surprisingly, WISP3 contained in conditioned medium recovered from transgenic mouse primary kidney cell cultures was able to bind BMP and to inhibit BMP signaling in vitro. Factors that account for the difference between the in vitro and in vivo activities of WISP3 remain unknown. At present, the mouse remains a challenging model organism in which to explore the biologic function of WISP3

Density Changes in Low Pressure Gas Targets for Electron Scattering Experiments

A system of modular sealed gas target cells has been developed for use in electron scattering experiments at the Thomas Jefferson National Accelerator Facility (Jefferson Lab). This system was initially developed to complete the MARATHON experiment which required, among other species, tritium as a target material. Thus far, the cells have been loaded with the gas species 3H, 3He, 2H, 1H and 40Ar and operated in nominal beam currents of up to 22.5 uA in Jefferson Lab's Hall A. While the gas density of the cells at the time of loading is known, the density of each gas varies uniquely when heated by the electron beam. To extract experimental cross sections using these cells, density dependence on beam current of each target fluid must be determined. In this study, data from measurements with several beam currents within the range of 2.5 to 22.5 uA on each target fluid are presented. Additionally, expressions for the beam current dependent fluid density of each target are developed.Comment: 8 pages, 12 figures, 4 table

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis and patho-physiological remodeling, in inflammation and in vascular biology. The human family includes 19 members that can be sub-grouped on the basis of their known substrates, namely the aggrecanases or proteoglycanases (ADAMTS1, 4, 5, 8, 9, 15 and 20), the procollagen N-propeptidases (ADAMTS2, 3 and 14), the cartilage oligomeric matrix protein-cleaving enzymes (ADAMTS7 and 12), the von-Willebrand Factor proteinase (ADAMTS13) and a group of orphan enzymes (ADAMTS6, 10, 16, 17, 18 and 19). Control of the structure and function of the extracellular matrix (ECM) is a central theme of the biology of the ADAMTS, as exemplified by the actions of the procollagen-N-propeptidases in collagen fibril assembly and of the aggrecanases in the cleavage or modification of ECM proteoglycans. Defects in certain family members give rise to inherited genetic disorders, while the aberrant expression or function of others is associated with arthritis, cancer and cardiovascular disease. In particular, ADAMTS4 and 5 have emerged as therapeutic targets in arthritis. Multiple ADAMTSs from different sub-groupings exert either positive or negative effects on tumorigenesis and metastasis, with both metalloproteinase-dependent and -independent actions known to occur. The basic ADAMTS structure comprises a metalloproteinase catalytic domain and a carboxy-terminal ancillary domain, the latter determining substrate specificity and the localization of the protease and its interaction partners; ancillary domains probably also have independent biological functions. Focusing primarily on the aggrecanases and proteoglycanases, this review provides a perspective on the evolution of the ADAMTS family, their links with developmental and disease mechanisms, and key questions for the future